PRODUCT DETAILS

About Arz-D 10mg/20mg Tablet

DOMPERIDONE+RABEPRAZOLE is a gastrointestinal medicine composed of Rabeprazole (stomach acid reducer) and Domperidone (nausea/vomiting reducer). Together they reduce the amount of acid your stomach makes and decrease the symptoms of nausea and vomiting. It treats symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat symptoms of gastroesophageal reflux disease (GERD).

GERD is a condition in which the sphincter (valve) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, the stomach acid and juice flow back into the food pipe, leading to stomach upset and heartburn. Heartburn is the post effect of the acid reflux with a burning-like feeling that rises from the stomach towards the neck.

DOMPERIDONE+RABEPRAZOLE contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor that helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall responsible for the release of gastric acid secretion damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone is a prokinetic agent that increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

It is better to take DOMPERIDONE+RABEPRAZOLE an hour before a meal or without a meal for its best results. DOMPERIDONE+RABEPRAZOLE should be swallowed whole with a glass of water. Do not chew, crush, or break it. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. An adult taking DOMPERIDONE+RABEPRAZOLE might have common side effects like headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children taking DOMPERIDONE+RABEPRAZOLE might report upper respiratory tract infections (URI), headache, fever, diarrhoea, vomiting, rash, and abdominal pain. These side effects are temporary and may get resolved after some time; however, if this side persists contact the doctor.

You can increase the efficacy of DOMPERIDONE+RABEPRAZOLE by taking a small meal or snacks frequently. Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes). Tell your doctor if you have stomach or intestinal cancer, liver problem, are allergic to DOMPERIDONE+RABEPRAZOLE or will have an endoscopy in the future. Prolonged intake of DOMPERIDONE+RABEPRAZOLE may cause deficiency of Vitamin B-12 and low levels of calcium, magnesium, and Vitamin D leading to osteoporosis (brittle or weak bones).

Uses of Arz-D 10mg/20mg Tablet

Gastro-Esophagal Reflux Disease (GERD), Acid reflux, Heartburn, Peptic ulcer, stomach ulcers, Dyspepsia (stomach discomfort due to indigestion)

Medicinal Benefits of Arz-D 10mg/20mg Tablet

DOMPERIDONE+RABEPRAZOLE helps in reducing the excess amount of stomach. In turn, it prevents the formation of an ulcer in the upper part of the intestine (duodenal ulcer), gastro-esophagal reflux disease (GERD) with or without ulcer, and Zollinger-Ellison Syndrome in which the stomach makes exceptionally high amounts of acid. Besides DOMPERIDONE+RABEPRAZOLE also treats symptoms of nausea and vomiting in adults and children more than 12 years of age (with at least 35 kg or more).

Directions for Use

It is better to take DOMPERIDONE+RABEPRAZOLE an hour before a meal. DOMPERIDONE+RABEPRAZOLE should be swallowed whole with a glass of water. Do not chew, crush, or break it. Besides this, DOMPERIDONE+RABEPRAZOLE is also available in liquid form for those who cannot swallow tablets or capsules. Do not take DOMPERIDONE+RABEPRAZOLE for more than 4 weeks of duration without consulting the doctor.

Side Effects of Arz-D 10mg/20mg Tablet

Every medicine has its own side effects. Likewise, DOMPERIDONE+RABEPRAZOLE also has some common side effects. An adult taking DOMPERIDONE+RABEPRAZOLE might have common side effects like rash, brittle bones, low vitamin B-12, loss of libido (sexual desire), cough, sore throat, runny nose, flatulence (gas formation), back pain, weakness or loss of strength, sleeplessness, headache, dizziness, and benign polyps in the stomach. These side effects are temporary and may get resolved after some time; however, if this side persists contact the doctor.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

You should avoid taking DOMPERIDONE+RABEPRAZOLE if you are allergic to DOMPERIDONE+RABEPRAZOLE or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. DOMPERIDONE+RABEPRAZOLE may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of DOMPERIDONE+RABEPRAZOLE may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B-12, and magnesium deficiency. Intake of DOMPERIDONE+RABEPRAZOLE may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool) immediately consult the doctor.  Tell your doctor that you are using before having a specific blood test known as Chromogranin A.

Drug Interactions

Drug-Drug Interaction:

 DOMPERIDONE+RABEPRAZOLE may interact with a blood thinner (clopidogrel, warfarin), antifungal (ketoconazole, voriconazole, itraconazole, fluconazole, posaconazole), anti-HIV drug (atazanavir, amprenavir, nelfinavir), antacid (magnesium hydroxide, aluminum hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), heart medicine (atropine, digoxin, amiodarone), blood pressure-lowering medicines (diltiazem), anti-cancer drug (methotrexate) and anti-nausea pills (aprepitant).

Drug-Disease Interaction:

DOMPERIDONE+RABEPRAZOLE should be not given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anemia), and low magnesium (hypomagnesemia).

Safety Advice

ALCOHOL

Drinking alcohol with DOMPERIDONE+RABEPRAZOLE may cause dehydration and elevate the level of stomach acid thereby decreasing its efficiency. So try to avoid, limit alcohol, or contact your doctor before intake of DOMPERIDONE+RABEPRAZOLE.

PREGNANCY

It is not known whether DOMPERIDONE+RABEPRAZOLE affects the baby or not. So, contact a doctor before intake of DOMPERIDONE+RABEPRAZOLE. Your doctor will weigh the benefits and any potential risks before prescribing them to you.

BREAST FEEDING

Domperidone present in DOMPERIDONE+RABEPRAZOLE passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of DOMPERIDONE+RABEPRAZOLE. Your doctor will weigh the benefits and any potential risks before prescribing them to you.

DRIVING

In some cases, DOMPERIDONE+RABEPRAZOLE may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.

LIVER

If u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking the medicine.

KIDNEY

If u have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking the medicine.